Article

Participant-Level Validation Reveals Optimistic Performance in Repeated-Measure NIPT Modeling: A Reproducibility Study

2026-07-28

Abstract excerpt

<title>Abstract</title> <p>Repeated non-invasive prenatal testing (NIPT) measurements from the same participant can be distributed across training and test sets when records are split at random, potentially inflating apparent model performance. We evaluated this risk in a de-identified repeated-measure benchmark dataset comprising 1082 male-fetus records from 267 participant codes and 605 female-fetus records fro...

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Literature Corpus work: f8db5bd6-81ac-5554-a0e1-2c76cb6d48a2
DOI: 10.21203/rs.3.rs-10475847/v1

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