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What constitutes safe and effective dose titration of methadone and buprenorphine/naloxone? protocol for a population-based target trial emulation

2026-07-27

Abstract excerpt

<h4>Introduction</h4> Clinical guidelines for managing opioid use disorder (OUD) recommend incremental dose titration for methadone and buprenorphine/naloxone to achieve a safe therapeutic maintenance dose. Dose titration recommendations are based on clinical experience, pharmacologic rationale, and expert consensus, with limited real-world evidence, especially in settings with widespread fentanyl use, where trad...

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Literature Corpus work
f7cc9d27-d638-5655-b4c1-8ea5b76c2d17
DOI
10.64898/2026.07.23.26358700
Open publication

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