Article

Immunogenicity of COVID-eVax Is Moderately Impacted by Temperature and Molecular Isoforms

2022-12-29

Abstract excerpt

DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we challenged this concept by characterizing the immunological response induced by a plasmid DNA vaccine delivered using electroporation. As a model, we used COVID-eVax, which...

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Identifiers and source

Literature Corpus work: f75ca657-d950-518f-898a-9b75f9b81327
DOI: 10.1101/2022.12.29.522202

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