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Masculinizing Testosterone Therapy Reduces the Incidence of PIK3CA-Mutant/ER⁺ Breast Cancer but Not BRCA1-Associated Triple-Negative Breast Cancer

2025-09-15

Abstract excerpt

<h4>Background</h4> We investigated the impact of gender-affirming testosterone therapy (TT) on breast cancer (BC) risk and tumor progression. <h4>Materials and methods</h4> We leveraged a large human breast tissue dataset (n=417) to assess TT and terminal duct lobular unit (TDLU) involution, complemented with tissue markers (ER, PR, AR, and Ki67; n =24) and transcriptome profiling ( n =8). Preclinical models as...

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Literature Corpus work
f5ca30ed-6d1f-5070-a0e6-b0ab18d8a4b5
DOI
10.1101/2025.09.15.25335324
Open publication

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