Article

Study protocol for an observational trial: Investigating pharmacogenetic impact on depression treatment using various sequencing and array methods (PharmGen-TRD Study)

2026-03-04

Abstract excerpt

<title>Abstract</title> <p>Antidepressant metabolism varies widely due to polymorphic cytochrome P450 (CYP) enzymeslike CYP2D6 and CYP2C19, of which various genetic variants exist. These variants influence serum concentrations, leading to side effects, low remission rates, and insufficient responses. Thus, physicians often try multiple antidepressants within a short period, causing increased psychological distres...

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Literature Corpus work: f588d32d-1aff-5b54-ab12-1a5cc3c2c888
DOI: 10.21203/rs.3.rs-9017719/v1

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