Article

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening

2021-07-05

Abstract excerpt

Drug development for specific antiviral agents against coronavirus disease 2019 (COVID-19) is still an unmet medical need as the pandemic continues to spread globally. Although huge efforts for drug repurposing and compound screens have put forth, only few compounds remain in late stage clinical trials. New approaches and assays are needed to accelerate COVID-19 drug discovery and development. Here we report a tim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f495b01b-9e2b-504f-a080-f0d435ccc418
DOI: 10.1101/2021.07.03.450938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screeningDOI 10.1101/2021.07.03.450938Read

A generic, scalable, and rapid TR-FRET –based assay for SARS-CoV-2 antigen detectionSemantic proximity Read

Rapid homogeneous assay for detecting antibodies against SARS-CoV-2Semantic proximity Read

Identifying Small-Molecule Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase by Establishing a Fluorometric AssaySemantic proximity Read

A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo.Semantic proximity Read

A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

A luminescent attenuated SARS-CoV-2 for the identification and validation of drug-resistant mutants.Semantic proximity Read

Screening of SARS-CoV-2 antivirals through a cell-based RNA-dependent RNA polymerase (RdRp) reporter assaySemantic proximity Read

A reporter cell line for the automated quantification of SARS-CoV-2 infection in living cellsSemantic proximity Read

Screening of SARS-CoV-2 Antivirals Through a Cell-Based RNA-Dependent RNA Polymerase (RdRp) Reporter AssaySemantic proximity Read

Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1Semantic proximity Read

FRET-Based haCE2 Receptor Mimic Peptide Conjugated Nanoprobe for Simple Detection of SARS-CoV-2Semantic proximity Read

Rapid <i>in vitro</i> assays for screening neutralizing antibodies and antivirals against SARS-CoV-2Semantic proximity Read