Article

Refining RDoC Using Individual-Level Task fMRI Factor Models Reveals Reproducible and Clinically Relevant Brain-Wide Motifs

2025-10-14

Abstract excerpt

The Research Domain Criteria (RDoC) framework was introduced to guide psychiatric research using biologically grounded, dimensional constructs of mental function. However, its hierarchical domain structure remains largely unvalidated against individual-level brain and behavioral data. Building on prior group-level work, we applied a multi-stage validation framework to Human Connectome Project (HCP) task-fMRI data...

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Literature Corpus work: f2f5146c-b6f4-5d98-aed2-e1340cdddf89
DOI: 10.1101/2025.10.13.682124

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