Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses

Abstract excerpt

Lagoviruses, family Caliciviridae , are some of the most virulent vertebrate viruses known. They infect leporids, i.e., rabbits ( Oryctolagus spp.), hares ( Lepus spp.) and cottontails ( Sylvilagus spp.) and rapidly kill over 95% of susceptible animals. Pathogenic lagoviruses are hepatotropic and induce a fulminant hepatitis that typically leads to disseminated intravascular coagulation within 24–72 hours of i...

Topics

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• Animal Virus Infections Studies
• Hepatitis B Virus Studies
• Hepatitis C virus research
• Hepatitis Viruses Studies and Epidemiology
• Liver Disease Diagnosis and Treatment
• Viral gastroenteritis research and epidemiology
• Viral Infections and Immunology Research
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

f2519cf0-e614-51d6-827b-63f0caeb352a

DOI

10.1101/2022.04.07.487566