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Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses

16 Aug 2023

Abstract excerpt

The genus Lagovirus of the family Caliciviridae contains some of the most virulent vertebrate viruses known. Lagoviruses infect leporids, such as rabbits, hares and cottontails. Highly pathogenic viruses such as Rabbit haemorrhagic disease virus 1 (RHDV1) cause a fulminant hepatitis that typically leads to disseminated intravascular coagulation within 24–72 h of infection, killing over 95 % of susceptible...

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PMID: 37584657
DOI: 10.1099/jgv.0.001874

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