Article

Application of CRISPR-Cas12a technology in zebrafish to simulate ß-globin gene (HBB) mutations

2023-09-23

Abstract excerpt

<h4>Background</h4> The human ß-globin (HBB) gene translated into the hemoglobin subunit beta (ß) of the hemoglobin protein. When mutated, it can lead to the blood disorder ß-thalassemia. Recently, the CRISPR-Cas12 technology has shown promising potential in treating different genetic abnormalities. <h4>Objectives</h4> This study aimed to evaluate the feasibility of zebrafish hbbe1.1 gene editing via CRISPR-Cas1...

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Literature Corpus work: f1beac2b-cc24-503a-9466-c035c9b2cbdf
DOI: 10.1101/2023.09.21.558926

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