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Article

Development of gene editing strategies for human β-globin (HBB) gene mutations.

Gene - 15 Apr 2020

Kalkan Batuhan Mert, Kala Ezgi Yagmur, Yuce Melek, Karadag Alpaslan Medine, Kocabas Fatih

Abstract excerpt

Recent developments in gene editing technology have enabled scientists to modify DNA sequence by using engineered endonucleases. These gene editing tools are promising candidates for clinical applications, especially for treatment of inherited disorders like sickle cell disease (SCD). SCD is caused by a point mutation in human β-globin gene (HBB). Clinical strategies have demonstrated substantial success, however...

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Identifiers

PMID: 31987908
DOI: 10.1016/j.gene.2020.144398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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