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Clear Cell Renal Cell Carcinoma: Unveiling Age-Linked Genetic Signatures, Relative Disease Aggressiveness, and Predictive Impact on Systemic Therapy

2024-12-31

Abstract excerpt

<h4>Summary</h4> <h4>Background and objectives</h4> Age influences the development and progression of clear cell renal cell carcinoma (ccRCC). Management of non-metastatic (M0) ccRCC involves surgery, adjuvant immune checkpoint inhibition (e.g., pembrolizumab) and surveillance. For metastatic (M1) ccRCC, treatment combines immune checkpoint inhibitors with anti-angiogenic therapies, achieving long-term remission i...

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Literature Corpus work: f0b64b39-00ff-531a-a2a4-ca628fcb4d49
DOI: 10.1101/2024.12.30.24317177

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