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A Leakage-Aware Machine Learning Framework for Multiclass Comorbidity Classification in Fibromyalgia: Integrating Genetic Feature Selection, Nested Cross-Validation, and Explainable AI

2026-08-05

Abstract excerpt

<title>Abstract</title> <p>Fibromyalgia frequently co-occurs with disc herniation and inflammatory bowel syndrome, and the overlapping symptom profiles of these conditions complicate differential diagnosis. This paper proposes a machine learning framework for three-class comorbidity classification that distinguishes No Comorbidity, Disc Herniation, and Inflammatory Bowel Syndrome from multi-instrument clinical as...

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Literature Corpus work: f08fa89a-058a-5fb3-9082-05ed62c109da
DOI: 10.21203/rs.3.rs-10433360/v1

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