Enhancement of mediodorsal thalamus rescues aberrant belief dynamics in a mouse model with schizophrenia-associated mutation

Abstract excerpt

Optimizing behavioral strategy requires belief updating based on new evidence, a process that engages higher cognition. In schizophrenia, aberrant belief dynamics may lead to psychosis, but the mechanisms underlying this process are unknown, in part, due to lack of appropriate animal models and behavior readouts. Here, we address this challenge by taking two synergistic approaches. First, we generate a mouse model...

Topics

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• Bayes Theorem
• Culture
• Models, Psychological
• Phenotype
• Schizophrenia
• Schizophrenic Psychology
• Schizotypal Personality Disorder
• Young Adult

Identifiers and source

Literature Corpus work

f02bd662-5996-53e3-b656-4ae5ab89c35d

DOI

10.1101/2024.01.08.574745