Article

Targeting multicopy prophage genes for the differential diagnosis of Lyme disease

2020-12-04

Abstract excerpt

The successful treatment of Lyme disease (LD) requires an accurate diagnostic test; however, most tests are insensitive and unspecific. To overcome these challenges, we developed and validated an internally-controlled quantitative PCR (Ter-qPCR) that targets the multicopy terminase large subunit ( terL ) gene encoded by prophages that are only found in LD-causing bacteria. The terL protein helps phages pack their...

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Literature Corpus work: ef5c67cd-cdfa-5516-bf8b-557c91263dbd
DOI: 10.1101/2020.12.02.20241687

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