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Article

Position-dependent effects of <i>SCN2A</i> premature stop codons on neuronal excitability and behavior

2025-10-31

Abstract excerpt

SCN2A encodes the voltage-gated sodium channel Na V 1.2, a key determinant of spike initiation and propagation in glutamatergic neurons. Premature termination codons are often assumed to produce uniform haploinsufficiency via nonsense-mediated decay, yet whether distinct SCN2A premature stop codons yield equivalent molecular, cellular, and behavioral outcomes remains unknown. We generated two mouse lines carryi...

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Literature Corpus work
eef905ce-86b5-5559-b3c0-ddafd942493e
DOI
10.1101/2025.10.30.685422
Open publication

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Position-dependent effects of <i>SCN2A</i> premature stop codons on neuronal excitability and behaviorDOI 10.1101/2025.10.30.685422
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