Article

Deep Learning-Based Screening for <i>POLE</i> mutations on Histopathology Slides in Endometrial Cancer

2026-02-09

Abstract excerpt

POLE sequencing for somatic mutations ( POLE mut) guides adjuvant therapy in endometrial cancer (EC), but cost and infrastructural considerations lead to limited uptake. Omission of POLE testing leads to unnecessary exposure to radiotherapy and/or chemotherapy. We developed POLARIX, a multiple instance deep learning model with attention pooling, which predicts POLE mutation status from routine hematoxylin and e...

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Literature Corpus work: eec0bcee-664e-56b1-be5a-f109c2c70a4d
DOI: 10.64898/2026.02.06.26345335

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