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The Conglomerate Theory of Aging: A Unified Model of Metal, AGE, and ALE Accumulation

2025-09-30

Abstract excerpt

The primary drivers of age-related decline remain incompletely understood despite progress in characterizing damage mechanisms. We propose the Conglomerate Theory of Aging, which identifies four key products of damage from multiple reactive species as primary contributors to biological aging: metal bioaccumulation, advanced glycation end products (AGEs), advanced lipoxidation end products (ALEs), and persistent me...

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Literature Corpus work
eea3aacd-0ab5-5f3a-8a53-079bcd1d9930
DOI
10.20944/preprints202509.2514.v1
Open publication

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The Conglomerate Theory of Aging: A Unified Model of Metal, AGE, and ALE AccumulationDOI 10.20944/preprints202509.2514.v1
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