Article

Longitudinal Profiling of the Intestinal Microbiome in Children with Cystic Fibrosis Treated with Elexacaftor-Tezacaftor-Ivacaftor

2023-08-16

Abstract excerpt

<h4>ABSTRACT</h4> The intestinal microbiome influences growth and disease progression in children with cystic fibrosis (CF). Elexacaftor-tezacaftor-ivacaftor (ELX/TEZ/IVA), the newest pharmaceutical modulator for CF, restores function of the pathogenic mutated CFTR channel. We performed a single-center longitudinal analysis of the effect of ELX/TEZ/IVA on the intestinal microbiome, intestinal inflammation, and cli...

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Literature Corpus work: ea0fdbb6-d2da-58a3-82fb-a25e64acc7be
DOI: 10.1101/2023.08.11.23293949

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