Article

Suppression of autophagy induces senescence in the heart

2024-05-30

Abstract excerpt

Aging is a critical risk factor for heart disease, including ischemic heart disease and heart failure. Cellular senescence, characterized by DNA damage, resistance to apoptosis and the senescence-associated secretory phenotype (SASP), occurs in many cell types, including cardiomyocytes. Senescence precipitates the aging process in surrounding cells and the organ through paracrine mechanisms. Generalized autophagy,...

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Literature Corpus work: ec304dc1-b1ea-5717-993a-aed9eb780ca7
DOI: 10.1101/2024.05.26.595978

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