Article

Defining and detecting global transcriptional amplitude in circadian gene expression

2025-11-16

Abstract excerpt

Many genes exhibit circadian rhythms in expression. The amplitude of oscillation, both in core clock and circadian output genes, may differ from person to person. Mutations in core clock genes are known to alter global rhythmic properties, and researchers often informally discuss “circadian amplitude.” Yet, it remains unclear whether, in the general population, differences in transcriptional amplitude are largely...

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Literature Corpus work: ebe96125-0c91-5cb1-9a5f-8d411e0e82a6
DOI: 10.1101/2025.11.14.688559

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