Article

PIK3CA-Mutated Colorectal Cancer Exhibits a Unique Gut Dysbiosis Profile: Insights from a Nationwide Pan-Cancer Screen in Japan

2026-01-12

Abstract excerpt

<title>Abstract</title> <p> Background While gut microbiota composition is increasingly linked to various solid tumors, the specific association with oncogenic driver mutations across different cancer types is not fully understood. <italic>PIK3CA</italic> mutations are known drivers in colorectal cancer (CRC) associated with therapeutic resistance. Methods and Results We conducted an analysis of fecal gut mi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea2dc8f7-0305-586f-a8e4-8ee2c3deb629
DOI: 10.21203/rs.3.rs-7874624/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PIK3CA-Mutated Colorectal Cancer Exhibits a Unique Gut Dysbiosis Profile: Insights from a Nationwide Pan-Cancer Screen in JapanDOI 10.21203/rs.3.rs-7874624/v1Read

Distinct Gut Microbiome Landscape of PIK3CA-Mutated Colorectal Cancer: A Nationwide Pan-Cancer Genomic and Microbial Profiling Study (MONSTAR-SCREEN)Semantic proximity Read

Microbiota disbiosis is associated with colorectal cancerSemantic proximity Read

Colorectal Cancer Stage-Specific Fecal Bacterial Community Fingerprinting of the Taiwanese Population and Underpinning of Potential Taxonomic BiomarkersSemantic proximity Read

Microbiome landscape and association with response to immune checkpoint inhibitors in advanced solid tumors: SCRUM-Japan MONSTAR-SCREENSemantic proximity Read

Tumor Tissue-Specific Bacterial Biomarker Panel for Colorectal Cancer: Bacteroides Massiliensis, Alistipes Species, Alistipes Onderdonkii, Bifidobacterium Pseudocatenulatum, Corynebacterium AppendicisSemantic proximity Read

Poor prognosis in IBD-complicated colon cancer through gut dysbiosis-related immune response failureSemantic proximity Read

Gut Microbiome-Driven Strategies to Overcome Immunotherapy Resistance in Microsatellite-Stable Colorectal CancerSemantic proximity Read

Catalog of gut microbiota alterations associated with anticancer therapies across multiple cancer typesSemantic proximity Read

Association Between Gut Microbiota and Digestive System Cancers: A Bidirectional Two-Sample Mendelian Randomization StudySemantic proximity Read

Advances in drug resistance and resistance mechanisms of four colorectal cancer-associated gut microbiotaSemantic proximity Read

A comprehensive analysis of the microbiota composition and gene expression in colorectal cancerSemantic proximity Read

Tumor-associated microbiome features of metastatic colorectal cancer and clinical implicationsSemantic proximity Read