Flexural Reticulate Hyperpigmentation Unmasking Dowling-Degos Disease: A Clinical and Histopathological Insight

Abstract excerpt

<title>Abstract</title> <p>Dowling-Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by progressive reticulate hyperpigmentation of flexural areas. We report the case of a 40-year-old woman who presented with gradually spreading lentiginous hyperpigmented macules involving the axillae, submammary folds, neck, and genital region. Clinical examination revealed no systemic associations, a...

Topics

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• Diagnosis, Differential
• Genetic Predisposition to Disease
• Hyperpigmentation
• Keratin-5
• Mutation
• Phenotype
• Pigmentation Disorders
• Skin Diseases, Genetic

Identifiers and source

Literature Corpus work

e88f4726-23f8-5ad5-a9a9-71ace7880025

DOI

10.21203/rs.3.rs-6745905/v1