Article

COVID-19 virtual patient cohort reveals immune mechanisms driving disease outcomes

2021-01-06

Abstract excerpt

To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results indicate that virtual patients with low production rates of infected cell derived IFN subsequently experienced highly inflammatory disease phenotypes, compared to those with early and...

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Literature Corpus work: e879014f-2c42-51d8-b3ac-6995726a8814
DOI: 10.1101/2021.01.05.425420

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