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COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes

14 Jul 2021

Abstract excerpt

To understand the diversity of immune responses to SARS-CoV-2 and distinguish features that predispose individuals to severe COVID-19, we developed a mechanistic, within-host mathematical model and virtual patient cohort. Our results suggest that virtual patients with low production rates of infected cell derived IFN subsequently experienced highly inflammatory disease phenotypes, compared to those with early and...

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PMID: 34260666
DOI: 10.1371/journal.ppat.1009753

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