Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation

Abstract excerpt

<h4>SUMMARY</h4> Probiotics have been widely used to improve impaired gastro-intestinal motility, yet their efficacy varied substantially across strains. Here, by a large-scale genetic screen plus in vivo measurements, we identified a key genetic factor ( abfA cluster governing arabinan utilization) in probiotic Bifidobacterium longum harnessing the treatment efficacy against functional constipation (FC). Intr...

Topics

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• Diet and metabolism studies
• Diet, Metabolism, and Disease
• Folate and B Vitamins Research
• Gastrointestinal motility and disorders
• Gut microbiota and health
• Helicobacter pylori-related gastroenterology studies
• Microbial Metabolites in Food Biotechnology
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

e7dbe5c2-ad8b-5599-9b3e-be70c0bcf272

DOI

10.1101/2022.12.15.518621