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Application of an Optimized Annotation Pipeline to the <i>Cryptococcus Deuterogattii</i> Genome Reveals Dynamic Primary Metabolic Gene Clusters and Genomic Impact of RNAi Loss

2020-09-01

Abstract excerpt

Evaluating the quality of a de novo annotation of a complex fungal genome based on RNA-seq data remains a challenge. In this study, we sequentially optimized a Cufflinks-CodingQuary based bioinformatics pipeline fed with RNA-seq data using the manually annotated model pathogenic yeasts Cryptococcus neoformans and Cryptococcus deneoformans as test cases. Our results demonstrate that the quality of the annotation...

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Literature Corpus work
e6404832-4df5-5ca9-ae13-e8fcb77cf882
DOI
10.1101/2020.09.01.278374
Open publication

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Application of an Optimized Annotation Pipeline to the <i>Cryptococcus Deuterogattii</i> Genome Reveals Dynamic Primary Metabolic Gene Clusters and Genomic Impact of RNAi LossDOI 10.1101/2020.09.01.278374
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