Article

Apathy precedes worsening depression, but not the reverse

2026-05-06

Abstract excerpt

Apathy–loss of motivation associated with diminished goal-directed behaviour–is among the most prevalent yet undertreated neuropsychiatric syndromes. Whether it represents a downstream residual manifestation of chronic depression or an independent and potentially upstream process remains unresolved. Here, leveraging two large-scale longitudinal psychiatric cohorts (N=2,482; age 24–93), we demonstrate that multidim...

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Literature Corpus work: e61e00fb-6163-5ee9-9e10-8073be140532
DOI: 10.64898/2026.05.05.26352457

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