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Article

GBP5 exacerbates rosacea-like skin inflammation by skewing macrophage polarization towards M1 phenotype through the NF-κB signalling pathway.

Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Apr 2023

Zhou Lei, Zhao Han, Zhao He, Meng Xin, Zhao Zhixiang, Xie Hongfu, Li Ji, Tang Yan, Zhang Yiya

Abstract excerpt

BACKGROUND: Rosacea is a chronic inflammatory skin disease with increased macrophage infiltration. However, the molecular mechanism remains unclear. OBJECTIVES: To determine the significance of macrophage infiltration, and the correlation between Guanylate-binding protein 5 (GBP5) and polarization of macrophages in rosacea-like inflammation. METHODS: Here we tested the hypothesis that Guanylate-binding protein 5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36367676
DOI: 10.1111/jdv.18725

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