Article

Advanced statistical methods in meta-analysis with applications in preclinical neurological drug discovery data

2021-01-01

Abstract excerpt

Conventional drug development generally starts with laboratory studies in animals, which can be used prior to testing safety and efficacy in humans to justify potential costs and risks. In the neurosciences, this has been characterised by substantial efficacy observed in animal studies that do not translate to similar efficacy in the clinic. This ~translational failure~ may in part be due to poor design and analys...

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Literature Corpus work: e5502728-81c8-5546-a039-de9d25ce778c
DOI: 10.7488/era/1396

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