Article

Inhibition of CDK4/6 Overcomes Primary Resistance to PD-1 Blockade in Malignant Mesothelioma

2021-03-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Despite the profound number of malignant pleural mesothelioma (MPM) patients now treated with PD-1 blockade, insight into the underpinnings of rational therapeutic strategies to treat resistance to checkpoint immunotherapy remain unrealized. Our objective was to develop a novel therapeutic approach to overcome primary resistance to PD-1 blockade in MPM. <h4>Methods</h4> We...

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Literature Corpus work: e46fa995-e234-50dc-897d-5eda90888103
DOI: 10.1101/2021.03.04.432811

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