Article

Unscheduled bleeding and endometrial cancer in women on postmenopausal hormone replacement therapy and their matched controls: protocol for a descriptive cohort study using the Orchid-e database

2026-04-18

Abstract excerpt

Hormone replacement therapy (HRT) with oestrogen and progestogen is a common medical treatment for alleviating symptoms of menopause. Since 2015, its use has been increasing in the UK. Unscheduled bleeding can be a symptom of endometrial cancer, and guidelines state that women experiencing this should have an urgent referral for suspected endometrial cancer. However, unscheduled bleeding is also common in women ta...

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Literature Corpus work: e420873b-b45a-5b3e-9c55-9adc5e011393
DOI: 10.64898/2026.04.17.26350707

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