Article
New Genotype Emergence of DENV are Constrained by the Double Host Selection, Reducing the Probability of Alternative Serotype Emergence
2019-05-15
Abstract excerpt
Since their discovery and sequencing 40 years ago, the DENV genotypes have shown an extreme coherence regarding the serotype class they code for. Considering the RNA virus mutation rate, we used Timed Markov Model to explore the transmission possibilities of mutated viruses and the statistical eventualities of new serotype emergence. We find that around 1 000 years are required for a new serotype to emerge, in lin...
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Identifiers and source
- Literature Corpus work
- e3fb6638-c85c-564f-a26e-4845f1402bdd
- DOI
- 10.1101/639849