Article

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosis

2020-03-12

Abstract excerpt

<h4>Summary</h4> Perturbations in the early life gut microbiome are associated with increased risk to complex immune disorder like inflammatory bowel diseases. We previously showed maternal antibiotic-induced gut dysbiosis vertically passed to offspring increases experimental colitis risk in IL-10 gene deficient (IL-10 −/− ) mice. While this could arise from emergence of pathobionts or loss/lack of essential mic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e30f569c-91ce-52dd-812d-0968039f70f9
DOI: 10.1101/2020.03.11.987412

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early-life microbial intervention reduces colitis risk promoted by antibiotic-induced gut dysbiosisDOI 10.1101/2020.03.11.987412Read

Metagenomic alterations in gut microbiota precede and predict onset of colitis in the IL10 gene-deficient murine modelSemantic proximity Read

Metagenomic Alterations in Gut Microbiota Precede and Predict Onset of Colitis in the IL10 Gene-Deficient Murine ModelSemantic proximity Read

Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice.Semantic proximity Read

Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone OffspringSemantic proximity Read

Intestinal microbiota: The explosive mixture at the origin of inflammatory bowel disease?Semantic proximity Read

Understanding the impact of antibiotic perturbation on the human microbiomeSemantic proximity Read

Untangling the Role of Pathobionts from Bacteroides Species in Inflammatory Bowel DiseasesSemantic proximity Read

Early Development of the Gut Microbiome and Immune-Mediated Childhood DisordersSemantic proximity Read

Establishing causality in Salmonella-microbiota-host interaction: The use of gnotobiotic mouse models and synthetic microbial communitiesSemantic proximity Read

Early-life exposures and the microbiome: implications for IBD preventionSemantic proximity Read

Gut microbiota differs between children with Inflammatory Bowel Disease and healthy siblings in taxonomic and functional composition: a metagenomic analysisSemantic proximity Read

Effects of Antibiotics on Human Microbiota and Subsequent DiseaseSemantic proximity Read