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A Cas9-fusion proximity-based approach generates an <i>Irak1-Mecp2</i> tandem duplication mouse model for the study of MeCP2 duplication syndrome

2023-02-07

Abstract excerpt

MECP2 duplication syndrome (MDS) is a neurodevelopmental disorder caused by tandem duplication of the MECP2 locus and its surrounding genes, including IRAK1 . Current MDS mouse models involve transgenic expression of MECP2 only, limiting their applicability to the study of the disease. Herein, we show that an efficient and precise CRISPR/Cas9 fusion proximity-based approach can be utilized to generate an Irak1...

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Literature Corpus work: e248a143-326e-5286-b872-9e1ca009a907
DOI: 10.1101/2023.02.07.527511

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