Article

SARS-CoV-2 RNA viremia is associated with a sepsis-like host response and critical illness in COVID-19

2020-08-31

Abstract excerpt

<h4>Background</h4> Severe COVID-19 is characterized by clinical and biological manifestations typically observed in sepsis. SARS-CoV-2 RNA is commonly detected in nasopharyngeal swabs, however viral RNA can be found also in peripheral blood and other tissues. Whether systemic spreading of the virus or viral components plays a role in the pathogenesis of the sepsis-like disease observed in severe COVID-19 is curre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e189a39d-f00c-5b01-aaf0-4a9a9f7bfe99
DOI: 10.1101/2020.08.25.20154252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 RNA viremia is associated with a sepsis-like host response and critical illness in COVID-19DOI 10.1101/2020.08.25.20154252Read

Discovery and Validation of a 3-Gene Transcriptional Signature to Distinguish COVID-19 and Other Viral Infections from Bacterial Sepsis in Adults; A Case-Control then Observational Cohort StudySemantic proximity Read

Pathophysiology of acute respiratory syndrome coronavirus 2 infection: a systematic literature review to inform EULAR points to consider.Semantic proximity Read

Clinical and molecular characteristics of COVID-19 patients with persistent SARS-CoV-2 infectionSemantic proximity Read

Immune Response and COVID-19: A mirror image of Sepsis.Semantic proximity Read

SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeuticsSemantic proximity Read

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patientsSemantic proximity Read

Predicting severity in COVID-19 disease using sepsis blood gene expression signaturesSemantic proximity Read

Bacterial sepsis causes more dramatic pathogenetic changes in the Th1 pathway than does viral (COVID-19) sepsis: a prospective observational study of whole blood transcriptomesSemantic proximity Read

Comparative Analysis of Host Responses Between Sepsis and COVID-19: A Prospective Observational Study of Whole Blood TranscriptomeSemantic proximity Read

Minimalistic Transcriptomic Signatures Permit Accurate Early Prediction of COVID-19 MortalitySemantic proximity Read

Deep RNA Sequencing of Intensive Care Unit Patients with COVID-19Semantic proximity Read

Association of SARS-CoV-2 Genomic Load with COVID-19 Patient OutcomesSemantic proximity Read