Article

Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriers

2025-06-19

Abstract excerpt

<title>Abstract</title> <p>The discovery that highly pathogenic avian influenza A(H5N1) virus exhibits a strong tropism for the bovine mammary gland1–4 represents a major shift in our understanding of influenza A virus host range and tissue specificity. We conducted a comprehensive series of experimental studies with influenza A(H5N1) B3.13 genotype in lactating dairy cattle to address several key questions relat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e02b3e84-6d93-5c39-b545-d1cf1a95ac74
DOI: 10.21203/rs.3.rs-6900680/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dairy cows infected with influenza A(H5N1) reveals low infectious dose and transmission barriersDOI 10.21203/rs.3.rs-6900680/v1Read

Dairy cows inoculated with highly pathogenic avian influenza virus H5N1.Semantic proximity Read

Pathogenesis of H5N1 Clade 2.3.4.4b in dry Jersey cows following intramammary inoculation shows within-host compartmentalizationSemantic proximity Read

Inoculation with highly pathogenic avian influenza H5N1 genotype D1.1 in naïve dairy cows and dairy cows previously exposed to genotype B3.13Semantic proximity Read

Natural H5N1 immunity in dairy cows is durable and cross-protective but non-sterilizingSemantic proximity Read

Highly pathogenic avian influenza virus H5N1 infection in dairy cows confers protective immunity against reinfectionSemantic proximity Read

Experimental reproduction of viral replication and disease in dairy calves and lactating cows inoculated with highly pathogenic avian influenza H5N1 clade 2.3.4.4bSemantic proximity Read

Influenza infection of the mammary glandSemantic proximity Read

Superior replication, pathogenicity, and immune evasion of a Texas dairy cattle H5N1 virus compared to a historical avian isolateSemantic proximity Read

Cross-Species Transmission of Highly Pathogenic Avian Influenza (HPAI) H5N1 Virus in the U.S. Dairy Cattle: A Comprehensive ReviewSemantic proximity Read

From birds to mammals: spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle led to efficient intra- and interspecies transmissionSemantic proximity Read

Susceptibility of calves fed unpasteurized milk from cows experimentally infected with highly pathogenic avian influenza H5N1Semantic proximity Read

Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like propertiesSemantic proximity Read