Article

Low-dose interleukin-2 for recurrent early pregnancy loss: a proof-of-concept study

2025-06-16

Abstract excerpt

<h4>Background</h4> Regulatory T cells (Tregs) are essential for maternal-fetal tolerance, and their deficiency has been implicated in immune-mediated pregnancy loss. Low-dose interleukin-2 (IL-2 LD ) selectively expands and activates Tregs and has shown efficacy in murine models of spontaneous immune-mediated miscarriage. This proof-of-concept study assessed the safety and efficacy of IL-2 LD in women with une...

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Literature Corpus work: de89c576-4dcb-5c51-aeb5-d50863eeab9b
DOI: 10.1101/2025.06.13.25328550

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