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Article

Characterisation of peri-implantation endometrial Treg and identification of an altered phenotype in recurrent pregnancy loss.

Mucosal immunology - 1 Jan 2022

Granne Ingrid, Shen Mengni, Rodriguez-Caro Helena, Chadha Gurmeher, O'Donnell Elizabeth, Brosens Jan J, Quenby Siobhan, Child Tim, Southcombe Jennifer H

Abstract excerpt

Recurrent Pregnancy Loss (RPL) affects 2-4% of couples, and with increasing numbers of pregnancy losses the risk of miscarrying a euploid pregnancy is increased, suggesting RPL is a pathology distinct from sporadic miscarriage that is due largely to lethal embryonic aneuploidy. There are a number of conditions associated with RPL including unspecified "immune" pathologies; one of the strongest candidates for...

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Identifiers

PMID: 34552206
DOI: 10.1038/s41385-021-00451-1
PMCID: PMC8732268

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