Article

Proteomic and Genomic Characterization of a Yeast Model for Ogden Syndrome

2016-03-21

Abstract excerpt

Naa10 is a Nα-terminal acetyltransferase that, in a complex with its auxiliary subunit Naa15, co-translationally acetylates the α-amino group of newly synthetized proteins as they emerge from the ribosome. Roughly 40-50% of the human proteome is acetylated by Naa10, rendering this an enzyme with one of the most broad substrate ranges known. Recently, we reported an X-linked disorder of infancy, Ogden syndrome, in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de517660-4c9a-5757-b2be-d6eb8cefe77f
DOI: 10.1101/045047

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteomic and Genomic Characterization of a Yeast Model for Ogden SyndromeDOI 10.1101/045047Read

A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant.Semantic proximity Read

NAA10-related syndromeSemantic proximity Read

The biological functions of Naa10 — From amino-terminal acetylation to human diseaseSemantic proximity Read

A novel NAA10 p.(R83H) variant with impaired acetyltransferase activity identified in two boys with ID and microcephalySemantic proximity Read

A novel NAA10 variant with impaired acetyltransferase activity causes developmental delay, intellectual disability, and hypertrophic cardiomyopathy.Semantic proximity Read

Human NAA30 can rescue yeast mak3∆ mutant growth phenotypes.Semantic proximity Read

Functional evaluation of NAA10 variants in patients with Ogden syndrome.Semantic proximity Read

Expanding the Phenotype Associated with NAA10-Related N-Terminal Acetylation Deficiency.Semantic proximity Read

Biochemical analysis of novel NAA10 variants suggests distinct pathogenic mechanisms involving impaired protein N-terminal acetylationSemantic proximity Read

De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females.Semantic proximity Read

NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy.Semantic proximity Read

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.Semantic proximity Read