Article

Spatially resolved mapping of histones reveal selective neuronal response in Rett syndrome

2025-06-25

Abstract excerpt

Rett Syndrome (RTT), a severe neurological disorder caused by loss-of-function mutations in the X-linked MECP2 gene, results in profound life-long neurological dysfunction. RTT patients live an apparently normal initial life until 12-18 months of age following which, a progressive accumulation of a wide range of phenotypic manifestations sets in. While MeCP2 is known to regulate chromatin, its impact on global hi...

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Literature Corpus work: dd640f01-bbb1-5ad4-be8b-150c176d6088
DOI: 10.1101/2025.06.23.661075

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