Intra-host evolution during relapsing parvovirus B19 infection in immunocompromised patients

Abstract excerpt

<h4>Introduction</h4> Parvovirus B19 (B19V) can cause severe relapsing episodes of anemia in immunocompromised individuals, which are commonly treated with intravenous immunoglobulins (IVIG). Few data is available on B19V intra-host evolution and the role of humoral immune selection. Here, we report the dynamics of genomic mutations and subsequent protein changes during relapsing infection. <h4>Methods</h4> Longit...

Topics

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• Genome, Viral
• Antibodies, Viral
• Hematologic Neoplasms
• Immunoglobulin G
• Incidence
• Parvoviridae Infections
• Parvovirus B19, Human
• Parvovirus B19 Infection Studies

Identifiers and source

Literature Corpus work

dd46cfdc-3eca-5005-8331-560514f13857

DOI

10.1101/2024.10.04.24314882