Article

Decoupling Detection and Classification to Improve Morphological Phenotype Analysis of Sickle Red Blood Cells in Full-Scope Microscopy

2026-04-06

Abstract excerpt

Microscopy-based analysis of red blood cell (RBC) morphology is widely used to study phenotypes in sickle cell disease (SCD). Although AI models have been developed to automate classification, most are trained on pre-cropped single-cell images and thus struggle with full-scope microscopic images containing densely packed cells and diverse morphologies, which require both accurate detection and fine-grained classif...

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Literature Corpus work: dcd64725-f39d-52f6-8659-cf17724aa15b
DOI: 10.64898/2026.03.31.715578

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