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Updates on the Role of Molecular Alterations and NOTCH Signaling in the Development of Neuroendocrine Neoplasms

2019-07-12

Abstract excerpt

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of rare malignancies mainly originated from hormones secreting cells, which are widespread in human tissues. The identification of mutations in ATRX/DAXX genes in sporadic NENs, as well as the high burden of mutations scattered throughout MEN-1 gene in both sporadic and inherited syndromes, provided new insights into the molecular biology of tumour dev...

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Literature Corpus work
dc1c7ac6-e096-56d8-abce-989c84f7243b
DOI
10.20944/preprints201907.0168.v1
Open publication

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