Article

Involvement of HIF-1/Trf/Fe2+ signaling pathway in the Pathogenesis of Stanford Type A Aortic Dissection

2025-12-08

Abstract excerpt

<title>Abstract</title> <p> Background Stanford type A aortic dissection (TAAD), as one of the most lethal cardiovascular disease, may be mediated by cellular ferroptosis, which exacerbates structural modification and dysfunction of endothelial and smooth muscle cells. Hypoxia inducible factor-1 (HIF-1), as a transcription factor has shown participate in the course of ferroptosis. However, the mechanism involved...

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Literature Corpus work: daaa0d99-7017-50b7-8993-18cf80b8d888
DOI: 10.21203/rs.3.rs-7845557/v1

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