Dynamic Profiling and Prediction of Antibody Response to Booster Inactivated Vaccines by Microsample-driven Biosensor and Machine Learning

Abstract excerpt

Knowledge on the antibody response to inactivated vaccines in third dose is crucial because it is one of the primary global vaccination programs. This study integrated microsampling with optical biosensors to profile neutralizing antibodies (NAbs) in fifteen vaccinated healthy donors, followed by application of machine learning to predict antibody response at given timepoints. Over a nine-month duration, microsamp...

Topics

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• Advanced Biosensing Techniques and Applications
• COVID-19 Clinical Research Studies
• interferon and immune responses
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• SARS-CoV-2 and COVID-19 Research
• SARS-CoV-2 detection and testing
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

da66e655-0564-5e00-804b-b432754f407b

DOI

10.1101/2024.01.25.24301760