Article

Novel use of imatinib to treat mandibular fibrous dysplasia in Noonan's syndrome

2023-01-28

Abstract excerpt

Fibrous dysplasia of the mandible typically begins during toddler years and culminates during puberty. These lesions may cause jaw disfigurement and may not be amendable to surgery. Imatinib successfully has treated cherubism associated with SH3BP2 mutations, but similar lesions can present in other conditions such as Noonan syndrome. We report diagnosis of Noonan syndrome caused by a PTPN11 activating mutation...

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Literature Corpus work: da2b6a04-1002-5a7f-8b40-5135c95dc10a
DOI: 10.22541/au.167492166.61754838/v1

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