Article

Rapid clonal selection within early hematopoietic cell compartments presages outcome to ivosidenib combination therapy

2024-12-31

Abstract excerpt

Acquired resistance to targeted non-intensive therapies is common in myeloid malignancies. Yet, key questions remain as to how rapidly resistant clones are selected by treatment and in which hematopoietic cell compartments clonal selection occurs. To address this gap, we studied clonal responses to ivosidenib + venetoclax +/- azacitidine combination therapy in 8 patients with IDH1-mutant myeloid malignancy. Whilst...

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Literature Corpus work: d8ef2c93-c7ef-5315-a832-ccf1e0045dfe
DOI: 10.1101/2024.12.30.630700

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