Article

T29C Polymorphism in the Transforming Growth Factor β1 Gene and Postmenopausal Breast Cancer Risk: The Multiethnic Cohort Study

2004-03-01

Abstract excerpt

Abstract Laboratory studies suggest a dual role for the transforming growth factor-β (TGF-β) signaling pathway in breast cancer. The normal antiproliferative activity of TGF-β in early breast tumor development is replaced by a promoting effect in later stages. A T29C transition polymorphism in the TGFB1 gene has been associated with higher circulating TGF-β1 levels, and inconsistently with breast cancer risk in th...

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Literature Corpus work: d836bce3-1b2a-5b55-b8b6-874d413c7ee1
DOI: 10.1158/1055-9965.412.13.3

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