Article

The viral accelerated NF-κB pathway drives COVID-19-associated coagulopathy via excessive transcription of tissue factor and plasminogen activator inhibitor 1 – case report

2021-07-27

Abstract excerpt

<title>Abstract</title> <bold>Background </bold>The current COVID-19 pandemic creates new clinical challenges almost daily, especially in terms of individual prognoses, diagnostics involving newly discovered pathogenic mechanisms, and the appearance of SARS-CoV-2 mutations. In terms of the thromboembolic complications frequently occurring in COVID-19 patients, there is new evidence that pathognomonic COVID-19-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7c331b9-9ea9-5383-9042-f0a8666068c5
DOI: 10.21203/rs.3.rs-382537/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The viral accelerated NF-κB pathway drives COVID-19-associated coagulopathy via excessive transcription of tissue factor and plasminogen activator inhibitor 1 – case reportDOI 10.21203/rs.3.rs-382537/v3Read

Interrelationship between COVID-19 and coagulopathy: pathophysiological and clinical evidenceSemantic proximity Read

Covid-19-associated coagulopathy (CoAC): thrombin burst and insufficient fibrinolysis leading to bad outcome.Semantic proximity Read

Severity-stratified and longitudinal analysis of VWF/ADAMTS13 imbalance, altered fibrin crosslinking and inhibition of fibrinolysis as contributors to COVID-19 coagulopathySemantic proximity Read

Systemic inflammation in COVID-19 patients may induce various types of venous and arterial thrombosis: A systematic review.Semantic proximity Read

Pathophysiology of SARS-CoV-2: targeting of endothelial cells renders a complex disease with thrombotic microangiopathy and aberrant immune response. The Mount Sinai COVID-19 autopsy experienceSemantic proximity Read

COVID-19 Clot: What Is It? Why in the Lungs? Extracellular Histone, “Auto-Activation” of Prothrombin, Emperipolesis, Megakaryocytes, “Self-Association” of Von Willebrand Factor and BeyondSemantic proximity Read

Effect of Hereditary Thrombophilia on the Clinical Severity of Covid-19 PneumoniaSemantic proximity Read

Mechanisms of Immunothrombosis by SARS-CoV-2Semantic proximity Read

Identification of potential coagulation pathway abnormalities in SARS-Cov-2 infection; insights from bioinformatics analysisSemantic proximity Read

COVID-19 Sepsis: Pathogenesis and Endothelial Molecular Mechanisms Based on "Two-Path Unifying Theory" of Hemostasis and Endotheliopathy-Associated Vascular Microthrombotic Disease, and Proposed Therapeutic Approach with Antimicrothrombotic Therapy.Semantic proximity Read

Transcriptome signatures preceding pulmonary arterial thrombosis in critically ill COVID-19 patientsSemantic proximity Read

Unique transcriptional changes in coagulation cascade genes in SARS-CoV-2-infected lung epithelial cells: A potential factor in COVID-19 coagulopathiesSemantic proximity Read